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CM2420 Part B

Healthy Participants 15 nights in-house + 2 visits
Study Focus:
Non-alcoholic Steatohepatitis
Administration:
Oral
Eligibility Requirements:
  • Males and females aged 18 to 55 years
  • BMI must be between 18 to 30kg/m²
  • Body weight must be between 45 to 100kg
  • Must be in good general health
  • Must not be taking any medications (other than contraception)
  • No blood donation 1 month prior
  • No significant allergies
  • Non-Smokers
  • No dietary requirements
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CM6521

New
Healthy Participants 15 nights + 2 follow up visits
Study Focus:
Rheumatoid Arthritis & NASH
Administration:
Oral Capsules
Eligibility Requirements:
  • Males and females aged 18 to 65 years
  • BMI must be between 18 to 32kg/m²
  • Body weight must be above 50kg
  • Must be in good general health
  • Must not be taking any medications
  • No significant allergies
  • No blood donation 3 months prior
  • Non-smokers
  • No dietary requirements
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CM5221

New
Healthy Participants 21 nights in house + 1 follow up visit + 1 phone call
Study Focus:
Thyroid Cancer
Administration:
Oral Capsules
Eligibility Requirements:
  • Males and females aged 18 to 55 years
  • Females must be of non-childbearing potential (postmenopausal or surgically sterile)
  • BMI must be between 18.5 to 30kg/m²
  • Must be in good general health
  • Must not be taking any medications
  • No significant allergies
  • No blood donation 2 months prior
  • Non-smokers
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CM8920 Part B

Healthy Participants 17 nights in-house + 1 visit
Study Focus:
Inflammatory Bowel Diseases
Administration:
Oral Tablet
Eligibility Requirements:
  • Males and females aged 18 to 55 years
  • BMI must be between 18 to 32kg/m²
  • Body weight must be above 55kg
  • Must be in good general health
  • Must not be taking any medications
  • No significant allergies
  • No blood donation 1 month prior
  • Non-smokers
  • No dietary requirements
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CM4821

New
Healthy Participants 4 x periods (4 nights + 5 visits each + 1 additional visit in period 4)
Study Focus:
Myeloid Malignancies
Administration:
Oral Capsule
Eligibility Requirements:
  • Males and females aged 18 to 65 years
  • BMI must be between 18 to 32kg/m²
  • Body weight must be between 55 – 100kg
  • Must be in good general health
  • Must not be taking any medications (other than contraception)
  • No blood donation 2 months prior
  • Non-smokers
  • No dietary requirements
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CM6321

New
Healthy Participants 2 in-house stays (8 nights each) + 5 Visits
Study Focus:
Non-Alcoholic Fatty Liver Disease
Administration:
Oral Tablet and Subcutaneous Injection
Eligibility Requirements:
  • Males and females aged 18 to 55 years
  • BMI must be between 28 to 40kg/m²
  • Must be in good general health
  • Must not be taking any medications (other than contraception)
  • No significant allergies
  • No blood donation 3 months prior
  • Non-smokers
  • No dietary requirements
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CM4621 Part B

Healthy Participants 12 nights in-house + 1 visit
Study Focus:
Inflammatory Bowel Disease
Administration:
Oral
Eligibility Requirements:
  • Males and females aged 18 to 65 years
  • Females must be of non-childbearing potential (surgically sterile or post-menopausal)
  • BMI must be between 18 to 32kg/m²
  • Must be in good general health
  • Must not be taking any medications
  • No significant allergies
  • Non-Smokers
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CM9320

Healthy Participants 17 nights in-house
Study Focus:
Antibiotic Resistance
Administration:
IV
Eligibility Requirements:
  • Males and females aged 18 to 55 years
  • BMI must be between 18.5 to 29.9kg/m²
  • Body weight must be between 55 to 100kg
  • Females must be of non-child bearing potential (surgically sterile or post-menopausal)
  • Must be in good general health
  • Must not be taking any medications
  • No blood donation 2 months prior
  • No significant allergies
  • Light smokers allowed
  • No dietary requirements
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CM4721

Healthy Participants 21 nights in-house + 1 visit
Study Focus:
Inflammatory Diseases
Administration:
Oral Tablet
Eligibility Requirements:
  • Males and females aged 18 to 45 years
  • BMI must be between 19 to 30kg/m²
  • Must be in good general health
  • Must not be taking any medications
  • No blood donation 2 months prior
  • No significant allergies
  • Non-Smokers
  • No dietary requirements
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CM4020 Part B

Healthy Participants 17 nights in-house + 1 visit
Study Focus:
Lysosomal Storage Disorders
Administration:
Oral
Eligibility Requirements:
  • Males and females aged 18 to 55 years
  • BMI must be between 18 to 30kg/m²
  • Must be in good general health
  • Must not be taking any medications (other than contraception)
  • No blood donation 3 months prior
  • No significant allergies
  • Non-Smokers
Read More

CM5021

Healthy Participants 20 nights in-house + 1 visit
Study Focus:
Auto-Immune Diseases
Administration:
Oral
Eligibility Requirements:
  • Males and females aged 18 to 60 years
  • BMI must be between 18 to 30kg/m²
  • Must be in good general health
  • Must not be taking any medications
  • No blood donation 3 months prior
  • No significant allergies
  • Non-Smokers
Read More

CM3820

Healthy Participants 30 nights in-house + 1 visit
Study Focus:
Serious Infections
Administration:
Oral Tablet
Eligibility Requirements:
  • Males and females aged 18 to 65 years
  • BMI must be between 18 to 30kg/m²
  • Body weight must be between 40 to 100kg
  • Must be in good general health
  • Must not be taking any medications (other than contraception)
  • No blood donation 1 month prior
  • No significant allergies
  • Non-Smokers
Read More

CM4921

Healthy Participants 11 night's in-house + 3 Visits
Study Focus:
Chronic Pain
Administration:
Oral Capsule
Eligibility Requirements:
  • Males and females aged 18 to 65 years
  • BMI must be between 18 to 32kg/m²
  • Body weight must be above 50kg
  • Must be in good general health
  • Must not be taking any medications (other than contraception)
  • No significant allergies
  • Non-Smokers
  • No dietary requirements
Read More

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